Clomid

Composition

One Clomid tablet contains 50 mg of Clomiphene Citrate.

Package

100 tablets in a sachet.

Pharmacological Effect

Anti-estrogenic.

Pharmacodynamics and Pharmacokinetics

It blocks receptors for estrogens in the ovaries and the hypothalamus, enhances the pituitary gland synthesis of the luteinizing hormone and follicle-stimulating hormone, which activates the maturation and hormonal function of the follicle; As a result - stimulates ovulation and increases the concentration of estradiol in the circulating blood.

Indications for Use

Infertility: dysfunctional metrorrhagia, anovulatory infertility, disgonadotropic form of amenorrhea, postcontraceptive or secondary amenorrhea, galactorrhea caused by pituitary tumor, Chiari-Frommel syndrome, oligospermia, androgen insufficiency, polycystic ovary syndrome, diagnosis of lesions of the secretory function of the pituitary gland.

Contraindications

Cryptogenic uterine bleeding, ovarian cyst, expressed hepatic or renal failure, pituitary tumor, bleeding, pituitary hypofunction, pregnancy.

Side Effects

Dizziness, hot flashes, nausea, headache, cystic enlargement of the ovaries, vision disorders.

Clomid, Instructions for Use (Method and Dosage)

The Clomid instructions indicate how to take this drug, recommending a dose for the first course of treatment of 50 mg daily for five days, starting from the fifth day of the menstrual cycle. In the absence of ovulation, there is no need to increase the dosage during subsequent courses of treatment.

Patients are worried about the question "what to do if the first course of Clomid did not help?" and "how to take it after the course of therapy?" Next, a second course of treatment (not earlier than one month after the end of the first course) is administered at a dosage of 100 mg daily for a period of 5 days.

During the third course, it is recommended to take 100 mg daily for a period of 5 days; Increasing the dose or duration of therapy, as in the second course, should not be done.

The most complete course of therapy for most patients is 3 cycles. If there is no effect after taking it, further treatment with Clomid is impractical.

Overdose

There are no reports of such cases.

Interaction

There is no clinically evidence of significant interactions with other drugs.

Storage Conditions

Store at temperatures up to 25°C. Keep away from children.

Shelf Life

5 years.

Special Instructions

Use of this drug increases the likelihood of multiple pregnancy. Clomid is effective at a sufficient concentration of endogenous estrogens, with a low concentration of estrogens it is less effective and almost ineffective with a low content of pituitary gonadotropic hormones.

During the therapy, regular monitoring of the gynecologist is necessary, it is necessary to monitor the operation of the ovaries, the examination of the vagina. Care must also be taken when driving.

Clomid Analogues

Analogues related to one group: Nolvadex, Nolvaxyl, Tamoximed, Tamodex.